Double Marker Screening 1st Trimester

Double Marker Test (PAPP-A and hCG) as a part of screening during the first-trimester of pregnancy is useful in assessing the risk of a fetus developing Down syndrome (trisomy 21- a genetic disease). The two markers included in this screening test include,

  1. Beta-hCG (beta human Chorionic Gonadotropin; placenta produces beta hCG hormone) and
  2. PAPP- A (Pregnancy Associated Plasma Protein) – a protein in the blood.
  3. The levels of both these substances are measured in the blood.
Why is the test performed?

The test is one of the options for prenatal Down syndrome screening.

When is the test recommended?

The test may be advised between the 11th and 14th weeks of pregnancy.

How is the sample collected?

A blood sample is collected from the vein in the arm of the individual using a needle.

How to prepare for the test?

As instructed by your gynaecologist.

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