Complement Level C4

Sample Type Blood
Pre-test Information 12 hours fasting is required before the test. This means you are not supposed to consume food or any other fluids, except water.
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Price ₹ 910
A critical element for activation of classical pathway is C4. Patients suffering from SLE, Immune complex disease and hereditary angioedema are found to have decreased levels of C4. Congenital deficiency of it can lead to increased risk of recurrent bacteremia especially S.pneumoniae. This evaluation helps in diagnosis of C4 deficiency and also for investigating patient with an undetectable Total complement level.

Frequently Asked Questions (FAQs)

The complement system is a major component of innate and adaptive immunity; upon activation, the complement results in the formation of the membrane attack complex (MAC) which releases peptides called anaphylatoxins. About 90% of complement components are synthesized in the liver and are acute-phase proteins. C4 is one of the activation proteins of the classic pathway. Decreased C4 levels Acquired autoimmune disorders, active phase of lupus erythematosus and rheumatoid arthritis. An undetectable C4 level (with normal C3) suggests a congenital C4 deficiency. Increased C4 levels Autoimmune hemolytic anemia.