Anca Profile (mpo & Pr3)
Sample Type | Blood |
Pre-test Information | 12 hours fasting is required before the test. This means you are not supposed to consume food or any other fluids, except water. |
Report Delivery | Same Day |
₹ Price | ₹ 2200 |
Frequently Asked Questions (FAQs)
c-ANCA testing is performed in the initial evaluation and follow-up of patients with Granulomatosis with Polyangiitis (GPA) previously known as Wegener's Granulomatosis(WG). Anti-neutrophil cytoplasmic antibodies (ANCA) are detected in sera of patients with Systemic vasculitis, Wegener's Granulomatosis, Microscopic Polyarteritis and other Small vessel vasculitis. Presence of c-ANCA antibodies in patients with small vessel vasculitis strongly suggests the diagnosis of WG in 95% of cases in the active generalized stage of the disease but a negative test result does not exclude the possibility of these disorders. c-ANCA disappears in majority of patients when treated with corticosteroids, cyclophosphamides or plasma exchange therapy. Reappearance of antibodies in these patients indicates recurrence. Myeloperoxidase or perinuclear antinuclear cytoplasmic antibody (p-ANCA) is useful in detecting several types of systemic necrotising vasculitis such as Microscopic polyarteritis and Crescentic glomerulonephritis. p-ANCA is found commonly in Churg Strauss syndrome and about 50% of patients with Ulcerative colitis. MPO- EIA test is recommended to confirm Anti MPO specificity because true ANA as well as granulocyte specific ANA are known to occur concurrently & Immunofluorescence methods may not adequately make this distinction. Hence a combination of Immunofluorescence & EIA methods are recommended for confirming presence of MPO antibody / p-ANCA.