C-anca (pr3) - Elisa

Frequently Asked Questions (FAQs)

C-ANCA testing is performed in the initial evaluation and follow-up of patients with Granulomatosis with Polyangiitis (GPA) previously known as Wegener's Granulomatosis(WG). Anti-neutrophil cytoplasmic antibodies (ANCA) are detected in sera of patients with Systemic vasculitis, Wegener's Granulomatosis, Microscopic Polyarteritis and other small vessel vasculitis. Presence of c-ANCA antibodies in patients with small vessel vasculitis strongly suggests the diagnosis of WG in 95% of cases in the active generalized stage of the disease but a negative test result does not exclude the possibility of these disorders. c-ANCA disappears in majority of patients when treated with corticosteroids, cyclophosphamides or plasma exchange therapy. Reappearance of antibodies in these patients indicates recurrence.