Activated Protein C Resistance (APC Resistance) Assay
Protein C is synthesized in the liver and is responsible for regulating blood clotting in the body. Thrombin bound to Thrombomodulin, cleaves protein C to form activated protein C, which is enzymatically active. Protein C is a natural anticoagulant that inactivates factors VIIIa and Va. A disorder in which APC does not inactivate factor V is known as APC resistance. This in a majority of the cases, happens due to incorrect gene mutations (factor V Leiden mutations). Therefore, in the patients with recurrent thromboembolism (VTE), the primary cause of thrombosis is most likely to be activated protein C resistance.
An Activated Protein C Resistance blood test is used to diagnose activated protein C resistance in the body
Why is the test performed?
Activated protein C resistance blood test is helpful in assessing the condition of patients with recurrent venous thromboembolism (VTE), as well as to monitor patients with a family history of VTE.
When is the test recommended?
The test may be recommended if VTE is recurrent and unprovoked and occurs at unusual sites, or occurs in patients with a family history of VTE. It is also recommended in women who have experienced VTE during pregnancy or unexplained pregnancy loss in their second or third trimesters.
How is the sample collected?
A blood sample is collected from a vein in the arm.
How to prepare for the test?
No special preparations are required for this test.