Anca Profile (mpo & Pr3)

Sample Type Blood
Pre-test Information 12 hours fasting is required before the test. This means you are not supposed to consume food or any other fluids, except water.
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₹ Price ₹ 2350
This test is conducted to detect and help in the diagnosis of a few types of autoimmune disorder systemic vasculitis, i.e. the inflammation of the blood vessels. And, it can also help monitor the same. This test also helps differentiate between Crohn disease and ulcerative colitis.

Frequently Asked Questions (FAQs)

c-ANCA testing is performed in the initial evaluation and follow-up of patients with Granulomatosis with Polyangiitis (GPA) previously known as Wegener's Granulomatosis(WG). Anti-neutrophil cytoplasmic antibodies (ANCA) are detected in sera of patients with Systemic vasculitis, Wegener's Granulomatosis, Microscopic Polyarteritis and other Small vessel vasculitis. Presence of c-ANCA antibodies in patients with small vessel vasculitis strongly suggests the diagnosis of WG in 95% of cases in the active generalized stage of the disease but a negative test result does not exclude the possibility of these disorders. c-ANCA disappears in majority of patients when treated with corticosteroids, cyclophosphamides or plasma exchange therapy. Reappearance of antibodies in these patients indicates recurrence. Myeloperoxidase or perinuclear antinuclear cytoplasmic antibody (p-ANCA) is useful in detecting several types of systemic necrotising vasculitis such as Microscopic polyarteritis and Crescentic glomerulonephritis. p-ANCA is found commonly in Churg Strauss syndrome and about 50% of patients with Ulcerative colitis. MPO- EIA test is recommended to confirm Anti MPO specificity because true ANA as well as granulocyte specific ANA are known to occur concurrently & Immunofluorescence methods may not adequately make this distinction. Hence a combination of Immunofluorescence & EIA methods are recommended for confirming presence of MPO antibody / p-ANCA.