17-alpha-hydroxyprogesterone (17-ohp)

Frequently Asked Questions (FAQs)

The analysis of 17-OHP is 1 of the 3 analytes along with cortisol and androstenedione that constitutes the best screening test for congenital adrenal hyperplasia (CAH) caused by either 11- or 21-hydroxylase deficiency. Measurement of 17-OHP concentrations is also utilized in evaluation of both men and women with acne vulgaris, male pattern baldness and in some subtle forms of infertility. More recently 17-OHP concentrations have been utilized in the evaluation of androgenized women where late onset 21-hydroxylase deficiency is suspected. In adult non-pregnant women in the childbearing age group, 17-OHP concentrations vary over the menstrual cycle with luteal phase concentrations being higher than follicular phase concentrations. There is also a diurnal variation of 17-OHP concentrations.