Myasthenia Gravis causes muscle weakness and easy fatigability. The most common cause behind this is autoantibody-mediated loss of functional acetylcholine receptors. These are present in the postsynaptic membrane of the skeletal muscles. The ACHR antibodies are not present in Congenital MG. The test is used to diagnose acquired forms of MG (90% positive), for detection of subclinical MG in recipients of D-penicillamine, Thymoma without clinical evidence of MG & Graft versus Host disease. The test may also turn out to be positive in Lambert-Eaton myasthenic syndrome, Auto-immune liver disease and Paraneoplastic autoimmune neurological disorders.
