This test is useful in the pathogenesis of a disease called Behcet's disease. HLA B5 has two splits B51 and B52. Out of which, only B51 is important in the etiology of Behcet's disease. Behcet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Human Leukocyte Antigen (HLA)-B5 and HLA- B51 genes are important in the pathogenesis of a disease. Positive result in the HLA- B51 test indicates increase in the risk for Behcet's disease by six times.
